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Characterization of imatinib mesylate formulations distributed in South American countries: Determination of genotoxic impurities by UHPLC-MS/MS and dissolution profile.
Wolff FC, Dillenburg TL, Venzon Antunes M, Linden R, Comparsi Wagner S, Verza SG. Wolff FC, et al. Biomed Chromatogr. 2018 Jul;32(7):e4222. doi: 10.1002/bmc.4222. Epub 2018 Apr 6. Biomed Chromatogr. 2018. PMID: 29488235
Therefore, in this work an analytical method using UHPLC-MS/MS was developed, validated and applied to characterize IM tablets for two GTIs: N-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine amine (Imp. 1), and N-[4-methyl-3-( …
Therefore, in this work an analytical method using UHPLC-MS/MS was developed, validated and applied to characterize IM tablets for two GTIs: …
Nonaqueous capillary electrophoresis of imatinib mesylate and related substances.
Ye L, Huang Y, Li J, Xiang G, Xu L. Ye L, et al. J Sep Sci. 2012 Aug;35(16):2108-13. doi: 10.1002/jssc.201200114. Epub 2012 Jul 2. J Sep Sci. 2012. PMID: 22753368
In the present study, nonaqueous capillary electrophoretic separation of imatinib mesylate (IM) and related substances, N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine (PYA), N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin …
In the present study, nonaqueous capillary electrophoretic separation of imatinib mesylate (IM) and related substances, N-(5-amino-2- …