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Poly[bis-[8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxyl-ato]cadmium].
Gao J, Gao J, Pei B, Huang J. Gao J, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 31;66(Pt 11):m1492. doi: 10.1107/S1600536810043291. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21588905 Free PMC article.
The title layered coordination polymer, [Cd(C(14)H(16)N(5)O(3))(2)](n) or [Cd(ppa)(2)](n), where ppa is 8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxyl-ate, was syn-thesized under hydro-thermal conditions. The Cd( …
The title layered coordination polymer, [Cd(C(14)H(16)N(5)O(3))(2)](n) or [Cd(ppa)(2)](n), where ppa is 8-ethyl-5-oxo-2-(piperazin- …
Poly[bis-[mu(2)-8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxyl-ato]nickel(II)].
An Z, Zhu L. An Z, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 Jan 9;66(Pt 2):m123. doi: 10.1107/S1600536809055408. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21579609 Free PMC article.
The title compound, [Ni(C(14)H(16)N(5)O(3))(2)](n) or [Ni(ppa)(2)](n), where ppa is 8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxyl-ate, was synthesized under hydro-thermal conditions. The Ni(II) atom (site symmet …
The title compound, [Ni(C(14)H(16)N(5)O(3))(2)](n) or [Ni(ppa)(2)](n), where ppa is 8-ethyl-5-oxo-2-(piperazin-1-yl)-5, …
Poly[[bis-[mu(2)-8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxyl-ato]cobalt(II)] dihydrate].
Qi X, Shao M, Li CX. Qi X, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 10;65(Pt 11):m1334. doi: 10.1107/S1600536809040185. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21578091 Free PMC article.
The title compound, {[Co(C(14)H(16)N(5)O(3))(2)].2H(2)O}(n) or [Co(ppa)(2)].2H(2)O}(n), where ppa denotes the 8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carb-ox-yl-ate anion, was synthesized under hydro-thermal condit …
The title compound, {[Co(C(14)H(16)N(5)O(3))(2)].2H(2)O}(n) or [Co(ppa)(2)].2H(2)O}(n), where ppa denotes the 8-ethyl-5-oxo-2-(piperazin …
Poly[[bis-[mu(2)-8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxyl-ato]zinc(II)] dihydrate].
Xu W, Zhu DS, Song XD, An Z. Xu W, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Sep 19;65(Pt 10):m1223. doi: 10.1107/S1600536809036939. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21577745 Free PMC article.
The title compound, {[Zn(C(14)H(16)N(5)O(3))(2)].2H(2)O}(n) or [Zn(ppa)(2)].2H(2)O}(n), where ppa = 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazin-yl)-pyrido(2,3-d)-pyrimidine-6-carboxyl-ate, was synthesized under hydro-thermal conditions. The Zn(II) atom (site symmetry ) …
The title compound, {[Zn(C(14)H(16)N(5)O(3))(2)].2H(2)O}(n) or [Zn(ppa)(2)].2H(2)O}(n), where ppa = 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazin …
Poly[[bis-[mu(2)-8-ethyl-5-oxo-2-(piperazin-1-yl)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxyl-ato]manganese(II)] dihydrate].
Huang J, Hu WP, An Z. Huang J, et al. Acta Crystallogr Sect E Struct Rep Online. 2008 Mar 14;64(Pt 4):m547. doi: 10.1107/S1600536808006533. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21202004 Free PMC article.
In the title compound, {[Mn(C(14)H(16)N(5)O(3))(2)].2H(2)O}(n), the Mn(II) atom (site symmetry ) exhibits a distorted trans-MnN(2)O(4) octa-hedral geometry defined by two monodentate N-bonded and two bidentate O,O'-bonded 8-ethyl-5-oxo-2-(piperazin-1-yl …
In the title compound, {[Mn(C(14)H(16)N(5)O(3))(2)].2H(2)O}(n), the Mn(II) atom (site symmetry ) exhibits a distorted trans-MnN(2)O(4 …
Bis[8-ethyl-5-oxo-2-(piperazin-4-ium-1-yl)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carb-oxy-lic acid] 2,5-dicarb-oxy-benzene-1,4-di-carboxyl-ate octa-hydrate.
Zhang GJ, He JH, Yan SW, Ye ZL, Xin GH. Zhang GJ, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 1;67(Pt 4):o1011-2. doi: 10.1107/S1600536811011068. Epub 2011 Mar 31. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 21754029 Free PMC article.
The asymmetric unit of the title compound, 2C(14)H(18)N(5)O(3) (+).C(10)H(5)O(8) (2-).8H(2)O, contains one [H(2)ppa](+)cation, one half of an [H(2)btec](2-) anion (H(4)btec = 1,2,4,5-benzene-tetra-carb-oxy-lic acid and Hppa = 8-ethyl-5-oxo-2-piperazin-1 …
The asymmetric unit of the title compound, 2C(14)H(18)N(5)O(3) (+).C(10)H(5)O(8) (2-).8H(2)O, contains one [H(2)ppa](+)cation, one half of a …
Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).
Reddy MV, Akula B, Cosenza SC, Athuluridivakar S, Mallireddigari MR, Pallela VR, Billa VK, Subbaiah DR, Bharathi EV, Vasquez-Del Carpio R, Padgaonkar A, Baker SJ, Reddy EP. Reddy MV, et al. J Med Chem. 2014 Feb 13;57(3):578-99. doi: 10.1021/jm401073p. Epub 2014 Jan 24. J Med Chem. 2014. PMID: 24417566 Free PMC article.
With this goal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structure-activity relationship trends that can be exploited in the design of potent kinase inhibitors. One compound, 8-cyclopentyl-2-[4-(4-methyl-piperazin …
With this goal in mind, we analyzed more than 150 novel cyano pyridopyrimidine compounds and identified structure-activity relationship tren …
Inhibitory effect of the new orally active CCR4 antagonist K327 on CCR4+CD4+ T cell migration into the lung of mice with ovalbumin-induced lung allergic inflammation.
Sato T, Komai M, Iwase M, Kobayashi K, Tahara H, Ohshima E, Arai H, Miki I. Sato T, et al. Pharmacology. 2009;84(3):171-82. doi: 10.1159/000235748. Epub 2009 Aug 27. Pharmacology. 2009. PMID: 19713720
CC chemokine receptor 4 (CCR4) is expressed on Th2 cells, found in inflamed tissues of allergic diseases, and is therefore suspected to be involved in the pathogenesis of allergic diseases by controlling Th2 cell migration into inflamed tissues. The aim of the present stud …
CC chemokine receptor 4 (CCR4) is expressed on Th2 cells, found in inflamed tissues of allergic diseases, and is therefore suspected …