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The following term was not found in PubMed: 3H-triazolo
Unknown field was ignored: [4,5-d]
Page 1
Structure and cytotoxic properties of 1-hydroxy-5-methyl-7-phenylpyrido[3,4-d]pyridazin-4(3H)-one and its mono- and disubstituted ethyl acetates.
Wójcicka A, Becan L, Rembiałkowska N, Pyra A, Bryndal I. Wójcicka A, et al. Acta Crystallogr C Struct Chem. 2022 Oct 1;78(Pt 10):559-569. doi: 10.1107/S2053229622009202. Epub 2022 Sep 23. Acta Crystallogr C Struct Chem. 2022. PMID: 36196789
Derivatives of pyrido[3,4-d]pyridazine, namely, 1-hydroxy-5-methyl-7-phenylpyrido[3,4-d]pyridazin-4(3H)-one dimethylformamide monosolvate, C(14)H(11)N(3)O(2).C(3)H(7)NO (2), ethyl [1-(2-ethoxy-2-oxoethoxy)-5-methyl-4-oxo-7-phenyl-3,4-dihydropyrido[3,4-d]pyridazin …
Derivatives of pyrido[3,4-d]pyridazine, namely, 1-hydroxy-5-methyl-7-phenylpyrido[3,4-d]pyridazin-4(3H)-one dimethylformamide …
Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines.
Hoffman GR, Schoffstall AM. Hoffman GR, et al. Molecules. 2022 Jul 22;27(15):4681. doi: 10.3390/molecules27154681. Molecules. 2022. PMID: 35897857 Free PMC article. Review.
Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. ...
Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. ...
Safe Synthesis of 4,7-Dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine and Its S(N)Ar Reactions.
Chmovzh TN, Knyazeva EA, Lyssenko KA, Popov VV, Rakitin OA. Chmovzh TN, et al. Molecules. 2018 Oct 9;23(10):2576. doi: 10.3390/molecules23102576. Molecules. 2018. PMID: 30304797 Free PMC article.
A safe and efficient synthesis of 4,7-dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine from the commercial diaminomaleonitrile is reported. Conditions for selective aromatic nucleophilic substitution of one or two bromine atoms by oxygen and nitrogen nucleophiles are found, wher …
A safe and efficient synthesis of 4,7-dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine from the commercial diaminomaleonitrile is reported. …
Synthesis of 3-(alpha- and beta-D-arabinofuranosyl)-6-chloro-1,2,4-triazolo[4,3-b]pyridazine.
Sala M, Jakse R, Svete J, Golobic A, Golic L, Stanovnik B. Sala M, et al. Carbohydr Res. 2003 Sep 26;338(20):2057-66. doi: 10.1016/s0008-6215(03)00347-1. Carbohydr Res. 2003. PMID: 14505872
Acid-catalysed treatment of (1S)- and (1R)-1-C-(6-chloro-1,2,4-triazolo[4,3-b]-pyridazin-3-yl)-2,3:4,5-di-O-isopropylidene-1-O-methanesulfonyl-D-arabinitols in refluxing 1,2-dimethoxyethane furnished 3-(alpha- and beta-D-arabinofuranosyl)-6-chloro-1,2,4-triazolo[4,3-b]p …
Acid-catalysed treatment of (1S)- and (1R)-1-C-(6-chloro-1,2,4-triazolo[4,3-b]-pyridazin-3-yl)-2,3:4,5-di-O-isopropylidene-1-O-methan …
[1,2,5]Thiadiazolo[3,4-d]Pyridazine as an Internal Acceptor in the D-A-pi-A Organic Sensitizers for Dye-Sensitized Solar Cells.
Chmovzh TN, Knyazeva EA, Tanaka E, Popov VV, Mikhalchenko LV, Robertson N, Rakitin OA. Chmovzh TN, et al. Molecules. 2019 Apr 22;24(8):1588. doi: 10.3390/molecules24081588. Molecules. 2019. PMID: 31013657 Free PMC article.
Four new D-A-pi-A metal-free organic sensitizers for dye-sensitized solar cells (DSSCs), with [1,2,5]thiadiazolo[3 ,4-d]pyridazine as internal acceptor, thiophene unit as pi-spacer and cyanoacrylate as anchoring electron acceptor, have been synthesized. The donor moiety wa …
Four new D-A-pi-A metal-free organic sensitizers for dye-sensitized solar cells (DSSCs), with [1,2,5]thiadiazolo[3 ,4-d]pyridazine as …
Superparamagnetic Poly(aniline-co-m-phenylenediamine)@Fe(3)O(4) Nanocomposite as an Efficient Heterogeneous Catalyst for the Synthesis of 1H-pyrazolo[1,2-a]pyridazine-5,8-diones & 1H-pyrazolo[1,2-b]phthalazine-5, 10-diones Derivatives.
Nezhad SM, Pourmousavi SA, Zare EN. Nezhad SM, et al. Curr Org Synth. 2022 Mar 3;19(2):246-266. doi: 10.2174/1570179418666211104143736. Curr Org Synth. 2022. PMID: 34736384
Then, the catalytic activity of the resulting superparamagnetic nanocomposite was investigated in the synthesis of 1H-pyrazolo[1,2-b]phetalazine-5,10-diones and 1H-pyrazolo[1,2-a]pyridazine-5,8-dione derivatives. A series of some 1H-pyrazolo[1,2-b]phetalazine-5,10-diones a …
Then, the catalytic activity of the resulting superparamagnetic nanocomposite was investigated in the synthesis of 1H-pyrazolo[1,2-b]phetala …
Thiazolo[4,5-d]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study.
Ewida MA, Abou El Ella DA, Lasheen DS, Ewida HA, El-Gazzar YI, El-Subbagh HI. Ewida MA, et al. Bioorg Chem. 2017 Oct;74:228-237. doi: 10.1016/j.bioorg.2017.08.010. Epub 2017 Aug 24. Bioorg Chem. 2017. PMID: 28865294
A new series of 1,3-thiazoles and thiazolo[4,5-d]pyridazine both bearing the 2-thioureido function were designed, synthesized and evaluated for their invitro DHFR inhibition and antitumor activities. ...
A new series of 1,3-thiazoles and thiazolo[4,5-d]pyridazine both bearing the 2-thioureido function were designed, synthesized and eva …
Imidazo[2',1':2,3]thiazolo[4,5-d]pyridazinone as a new scaffold of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study.
Ewida MA, Abou El Ella DA, Lasheen DS, Ewida HA, El-Gazzar YI, El-Subbagh HI. Ewida MA, et al. Bioorg Chem. 2018 Oct;80:11-23. doi: 10.1016/j.bioorg.2018.05.025. Epub 2018 May 26. Bioorg Chem. 2018. PMID: 29864684
New series of thiazolo[4,5-d]pyridazin and imidazo[2',1':2,3]thiazolo[4,5-d]pyridazin analogues were designed, synthesized and evaluated for their invitro DHFR inhibition and antitumor activity. ...Ring annexation of the active 1,3-thiazole ring analogue 13 into the …
New series of thiazolo[4,5-d]pyridazin and imidazo[2',1':2,3]thiazolo[4,5-d]pyridazin analogues were designed, synthesized and …
Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides.
Bussolari JC, Ramesh K, Stoeckler JD, Chen SF, Panzica RP. Bussolari JC, et al. J Med Chem. 1993 Dec 10;36(25):4113-20. doi: 10.1021/jm00077a017. J Med Chem. 1993. PMID: 8258836
The chemical synthesis of certain N4-substituted imidazo[4,5-d]pyridazine and v-triazolo[4,5-d]-pyridazine nucleosides is described. In both series, the 4-chloro analogues, i.e., 4-chloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)imidazo[4,5-d]pyr idazine (5a) and …
The chemical synthesis of certain N4-substituted imidazo[4,5-d]pyridazine and v-triazolo[4,5-d]-pyridazine nucleosides is desc …
Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.
Giovannoni MP, Ciciani G, Cilibrizzi A, Crocetti L, Daniele S, Di Cesare Mannelli L, Ghelardini C, Giacomelli C, Guerrini G, Martini C, Trincavelli ML, Vergelli C. Giovannoni MP, et al. Eur J Med Chem. 2015 Jan 7;89:32-41. doi: 10.1016/j.ejmech.2014.10.020. Epub 2014 Oct 12. Eur J Med Chem. 2015. PMID: 25462223
A new series of pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones was synthesized and tested in radioligand binding assays on human A1, A2A and A3 adenosine receptors. ...
A new series of pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones was synthesized and tested in radioligand binding assays on hu …
19,265 results
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