Salmonella osteomyelitis of the hand unassociated with hemoglobinopathy developed in a 39-year-old woman. After 11 debridement and curettage operations on the affected finger, she was successfully treated with excision of the diseased bone and reconstruction with a silicone prosthesis and extensor indicis transfer. This patient, examined 19 years after the onset of symptoms, illustrates that Salmonella osteomyelitis may persist for an exceedingly long period when limited curettage is the only method of treatment.