Might the observed α(2A)-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?
Diamanti E, Del Bello F, Carbonara G, Carrieri A, Fracchiolla G, Giannella M, Mammoli V, Piergentili A, Pohjanoksa K, Quaglia W, Scheinin M, Pigini M.
Diamanti E, et al.
Bioorg Med Chem. 2012 Mar 15;20(6):2082-90. doi: 10.1016/j.bmc.2012.01.035. Epub 2012 Jan 31.
Bioorg Med Chem. 2012.
PMID: 22341244
To highlight the molecular characteristics compatible with this behaviour and to obtain novel agents potentially useful in chronic pain and opioid addiction management, the allyl group of 9 was replaced by substituents of moderate steric bulk (MR) and positive or negative lipophi …
To highlight the molecular characteristics compatible with this behaviour and to obtain novel agents potentially useful in chronic pain and …