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1993 1
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2009 1
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Evaluation of fluoren-NU as a novel antitumor agent.
Mukherjee A, Dutta S, Chashoo G, Bhagat M, Saxena AK, Sanyal U. Mukherjee A, et al. Oncol Res. 2009;17(9):387-96. doi: 10.3727/096504009788912516. Oncol Res. 2009. PMID: 19718945
A new nitrososourea derivative, namely fluoren-NU, 3-[2-(3-(2-chloroethyl)-3-nitrosouriedo}ethyl]-spiro[5,9'-fluorenyl]imidazolidine-2,4-dione (compound 2e), was synthesized from 3-(2-bromoethyl)-spiro [5,9'-fluorenyl]imidazolidine-2,4-dione via a four-step s …
A new nitrososourea derivative, namely fluoren-NU, 3-[2-(3-(2-chloroethyl)-3-nitrosouriedo}ethyl]-spiro[5,9'-fluorenyl] …
Modulation of the potency of promutagens and direct acting mutagens in bacteria by inhibitors of the multidrug resistance mechanism.
De Flora S, Camoirano A, Cartiglia C, Ferguson L. De Flora S, et al. Mutagenesis. 1997 Nov;12(6):431-5. doi: 10.1093/mutage/12.6.431. Mutagenesis. 1997. PMID: 9412996
Neither verapamil nor trifluoperazine affected the direct mutagenicity of sodium dichromate and 2-methoxy-6-chloro-9[3-(2-chloroethyl)amino-propyl-amino] dihydrochloride (ICR 191) or the S9-mediated mutagenicity of benzo[a]pyrene and 2-amino-3,4-dimethyl-amid …
Neither verapamil nor trifluoperazine affected the direct mutagenicity of sodium dichromate and 2-methoxy-6-chloro-9[3-(2-c …
Comparative studies between the effects of mitozolomide and two novel tetrazepinones PYRCL and QUINCL on NIH:OVCAR-3 cells.
Jean-Claude BJ, Mustafa A, Damian Z, De Marte J, Vasilescu DE, Yen R, Chan TH, Leyland-Jones B. Jean-Claude BJ, et al. Cancer Chemother Pharmacol. 1998;42(1):59-67. doi: 10.1007/s002800050785. Cancer Chemother Pharmacol. 1998. PMID: 9619759
Cytotoxicity, reduction of macromolecule synthesis and cell cycle perturbations by two novel 3-(2-chloroethyl)-tetrazepinones, PYRCL and QUINCL were compared with those produced by the structurally related 3-(2-chloroethyl)-tetrazinone, m …
Cytotoxicity, reduction of macromolecule synthesis and cell cycle perturbations by two novel 3-(2-chloroethyl)-tetrazep …
Effect of chemoradiotherapy using ACNU, vincristine, and nicardipine with high-dose irradiation on malignant astrocytomas.
Genka S, Shitara N, Nakamura H, Takakura K. Genka S, et al. Neurol Med Chir (Tokyo). 1993 May;33(5):295-9. doi: 10.2176/nmc.33.295. Neurol Med Chir (Tokyo). 1993. PMID: 7687035 Free article.
Twenty-five patients (Group 1) received 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea hydrochloride (ACNU), vincristine, and 60 Gy of irradiation, and 27 patients (Group 2) ACNU, vincristine, the Ca-channel blocker nicardipine, and …
Twenty-five patients (Group 1) received 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea hydro …
Reversal of chemoresistance in malignant gliomas by calcium antagonists: correlation with the expression of multidrug-resistant p-glycoprotein.
Kiwit JC, Hertel A, Matuschek AE. Kiwit JC, et al. J Neurosurg. 1994 Oct;81(4):587-94. doi: 10.3171/jns.1994.81.4.0587. J Neurosurg. 1994. PMID: 7931593
The authors used a microtiter tetrazolium test to analyze primary in vitro chemoresistance and chemosensitivity of 15 early cultures of human malignant glioma exposed to 50 micrograms/ml (1,4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosoure …
The authors used a microtiter tetrazolium test to analyze primary in vitro chemoresistance and chemosensitivity of 15 early cultures of huma …