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Implications of N-capped urea/thiourea and C-capped 3-(1-piperazinyl)-1,2-benzisothiazole with bridging Gly-Val/Phe-Gly-Val-Pro as therapeutic targets.
Sharma A, Suhas R, Banu SH, Chandrashekar S, Gowda DC. Sharma A, et al. Eur J Med Chem. 2014 Nov 24;87:657-61. doi: 10.1016/j.ejmech.2014.09.098. Epub 2014 Oct 2. Eur J Med Chem. 2014. PMID: 25305332
A series of urea/thiourea derivatives were synthesized by using peptides conjugated to 3-(1-piperazinyl)-1,2-benzisothiazole and their structure was characterized by analytical and spectral ((1)H, (13)C NMR and Mass) methods. ...
A series of urea/thiourea derivatives were synthesized by using peptides conjugated to 3-(1-piperazinyl)-1,2 …
Ureas/thioureas of benzo[d]isothiazole analog conjugated glutamic acid: synthesis and biological evaluation.
Sharma A, Suhas R, Gowda DC. Sharma A, et al. Arch Pharm (Weinheim). 2013 May;346(5):359-66. doi: 10.1002/ardp.201200470. Epub 2013 Apr 16. Arch Pharm (Weinheim). 2013. PMID: 23589361
A series of urea and thiourea derivatives of glutamic acid conjugated to 3-(1-piperazinyl)-1,2-benzisothiazole were synthesized, spectroscopically characterized, and evaluated for their in vitro antiglycation and urease inhibitory activit …
A series of urea and thiourea derivatives of glutamic acid conjugated to 3-(1-piperazinyl)-1,2-benziso …
Novel urea and thiourea derivatives of thiazole-glutamic acid conjugate as potential inhibitors of microbes and fungi.
Sharma A, Suhas R, Chandan S, Gowda DC. Sharma A, et al. Bioorg Khim. 2013 Nov-Dec;39(6):736-44. Bioorg Khim. 2013. PMID: 25696935
In the present study, several N-terminal substituted urea/thiourea derivatives were synthesized by the reaction of glutamic acid and 3-(1-piperazinyl)-1,2-benzisothiazole with various substituted phenyl isocyanates/isothiocyanates. ...
In the present study, several N-terminal substituted urea/thiourea derivatives were synthesized by the reaction of glutamic acid and 3 …