Format

Send to:

Choose Destination
See comment in PubMed Commons below
Comp Med. 2014 Jun;64(3):211-20.

Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta).

Author information

  • 1Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticu, USAt.
  • 2Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
  • 3Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • 4Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. steven.r.wilson@yale.edu.

Abstract

Two aged female rhesus macaques (Macaca mulatta) presented with weight loss and intermittent inappetence. The signalment and constellation of clinical signs led clinicians to suspect the presence of intestinal adenocarcinoma. Because of each animal's advanced age and inconclusive radiographic findings, a noninvasive diagnostic tool was preferred over exploratory laparotomy to assist in determining a diagnosis. Consequently, 2-[(18)F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography-CT (FDG-PET-CT) was chosen to aid in confirming a suspicion of gastrointestinal adenocarcinoma in both animals. FDG is a glucose analogue labeled with fluorine-18 and is taken up by highly metabolically active cells, as observed in many cancers. Tomography revealed an annular constriction of the small intestine with focal FDG uptake in one animal, and an FDG avid transmural mass in the ascending colon of the second animal. Necropsy later confirmed both sites to be adenocarcinomas. This report supports the use of FDG-PET-CT as an adjunct to conventional radiography in the diagnosis of intestinal adenocarcinoma in nonhuman primates.

PMID:
24956213
[PubMed - in process]
PMCID:
PMC4067585
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Ingenta plc Icon for PubMed Central
    Loading ...
    Write to the Help Desk