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Nat Neurosci. 2014 Jul;17(7):908-10. doi: 10.1038/nn.3725. Epub 2014 Jun 1.

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.

Author information

  • 1Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
  • 21] Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Institute of Anatomy, University of Leipzig, Leipzig, Germany.
  • 3Hospital Infantil Universitario Niño Jesús, Department of Endocrinology, Instituto de Investigación La Princesa and Centro de Investigación Biomédica en Red de la Fisiopatología (CIBER) de Fisiopatología de Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
  • 41] Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA.
  • 5Institute for Diabetes and Obesity, Helmholtz Zentrum München & Technische Universität München, Germany.
  • 6Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA.
  • 71] Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • 81] Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [2] Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA. [3] Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

Abstract

We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.

PMID:
24880214
[PubMed - indexed for MEDLINE]
PMCID:
PMC4113214
Free PMC Article
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