Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Reprod Immunol. 2014 Oct;72(4):422-34. doi: 10.1111/aji.12274. Epub 2014 May 28.

Circulating cytokines and alarmins associated with placental inflammation in high-risk pregnancies.

Author information

  • 1Maternal and Fetal Health Research Centre, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK; Manchester Academic Health Science Centre, St. Mary's Hospital, Central Manchester University Hospital NHS Foundation Trust, Manchester, UK; Faculty of Life Sciences, University of Manchester, Manchester, UK.

Abstract

PROBLEM:

Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment.

METHOD OF STUDY:

The inflammatory profile of villous tissue was studied in pregnancies at high-risk of placental dysfunction and compared to uncomplicated pregnancies. The systemic inflammatory profile was assessed in matched maternal serum samples in cases of reduced fetal movements (RFM).

RESULTS:

Placentas from RFM pregnancies had a unique inflammatory profile characterized by increased interleukin (IL)-1 receptor antagonist and decreased IL-10 expression, concomitant with increased numbers of placental macrophages. This aberrant cytokine profile was evident in maternal serum in RFM, as were increased levels of alarmins (uric acid, HMGB1, cell-free fetal DNA).

CONCLUSION:

This distinct inflammatory profile at the maternal-fetal interface, mirrored in maternal serum, could represent biomarkers of placental inflammation and could offer novel therapeutic options to protect the placenta and fetus from an adverse maternal environment.

© 2014 The Authors. American Journal of Reproductive Immunology Published by John Wiley & Sons Ltd.

KEYWORDS:

High-risk pregnancy; inflammation; placental dysfunction; stillbirth

PMID:
24867252
[PubMed - in process]
PMCID:
PMC4369138
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing Icon for PubMed Central
    Loading ...
    Write to the Help Desk