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Ann Allergy Asthma Immunol. 2014 Jun;112(6):519-24. doi: 10.1016/j.anai.2014.03.017. Epub 2014 Apr 16.

Effect of vitamin D-binding protein genotype on the development of asthma in children.

Author information

  • 1Section of Respiratory Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
  • 2Yale Center for Analytical Sciences, Yale School of Public Health, New Haven, Connecticut.
  • 3Departments of Laboratory Medicine and Pathobiology, Medicine, and Genetics, University of Toronto, Toronto, Ontario, Canada.
  • 4Section of Endocrinology, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
  • 5Section of Respiratory Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut. Electronic address: alia.bazzy-asaad@yale.edu.

Abstract

BACKGROUND:

Potential vitamin D-related influences on inflammatory diseases such as asthma are controversial, including the suggestion that vitamin D insufficiency is associated with increased asthma morbidity. Vitamin D-binding protein transports vitamin D metabolites in the circulation. Single nucleotide polymorphisms in the GC gene encoding vitamin D-binding protein are associated with circulating vitamin D metabolite levels in healthy infants and toddlers.

OBJECTIVE:

To test the hypothesis that GC single nucleotide polymorphisms encoding the D432E and T436K variants predict subsequent development of asthma in healthy children.

METHODS:

A retrospective medical record review was performed to determine the development of asthma in 776 children in whom GC genotype, vitamin D-binding protein concentration, and circulating 25-hydroxyvitamin D had been determined at 6 to 36 months of age. Demographic and detailed current clinical data were collected and criteria for asthma were recorded.

RESULTS:

GC genotype was available for 463 subjects. After an initial analysis of all subject data, the analysis was limited to the predominant Hispanic population (72.1%) to minimize potential confounding effects of ethnicity. Asthma was diagnosed in 87 children (26%). Subjects with the GC genotype encoding the ET/ET (Gc1s/Gc1s) variant had lower odds of developing asthma, representing a protective effect compared with subjects with the DT/DT (Gc1f/Gc1f) variant.

CONCLUSION:

In the Hispanic population of inner-city New Haven, Connecticut, the ET/ET (Gc1s/Gc1s) genotype of vitamin D-binding protein might confer protection against the development of asthma compared with the wild-type genotype DT/DT (Gc1f/Gc1f).

Copyright © 2014 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

PMID:
24745702
[PubMed - indexed for MEDLINE]
PMCID:
PMC4070170
[Available on 2015-06-01]
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