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Front Behav Neurosci. 2014 Feb 13;8:42. doi: 10.3389/fnbeh.2014.00042. eCollection 2014.

Lesions of the dorsomedial striatum delay spatial learning and render cue-based navigation inflexible in a water maze task in mice.

Author information

  • 1Department of Psychiatry, Yale University New Haven, CT, USA ; Weill Cornell Graduate School New York, NY, USA.
  • 2Department of Psychiatry, Yale University New Haven, CT, USA.
  • 3Department of Psychiatry, Yale University New Haven, CT, USA ; Department of Psychology, Yale University New Haven, CT, USA ; The Child Study Center, Yale University New Haven, CT, USA.

Abstract

The dorsal striatum is involved in cue-based navigation strategies and in the development of habits. It has been proposed that striatum-dependent cued navigation competes with hippocampus-dependent spatial navigation in some circumstances. We have previously shown that large lesions of the dorsal striatum, as well as impairment of corticostriatal synaptic plasticity in transgenic mice, can enhance spatial learning in a water maze task, presumably by the disruption of competitive interference. However, the dorsal striatum is not a homogeneous structure; both anatomical considerations and experimental studies in various paradigms show that dorsomedial and dorsolateral striatum are functionally distinct, although there is no precise anatomical or neurochemical boundary between them. Here we investigated the effect of restricted excitotoxic lesions of dorsomedial striatum (DMS) on cued and spatial water maze learning. We find that dorsomedial striatal lesions delay spatial learning but permit cued learning. After cued learning, lesioned animals showed inflexible search, resulting in repeated visits to the escape platform-associated cue. These results support a role for the DMS in behavioral flexibility rather than in cue-based navigation.

KEYWORDS:

basal ganglia; behavioral flexibility; habit; learning; mouse; striatum

PMID:
24592223
[PubMed]
PMCID:
PMC3923143
Free PMC Article
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