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Cell Signal. 2014 Jun;26(6):1173-81. doi: 10.1016/j.cellsig.2014.01.033. Epub 2014 Feb 9.

Adenylyl cyclases in the digestive system.

Author information

  • 1Department of Biological Sciences, Georgia Regents University, United States. Electronic address:
  • 2Department of Cell Biology and Medicine, Yale University, United States; VA CT, United States.
  • 3Department of Internal Medicine, Scott & White-Digestive Disease Research Center, Texas A&M Health Science Center, Central Texas Veterans Health Care System, United States.


Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.

Copyright © 2014 Elsevier Inc. All rights reserved.


Adenylyl cyclase; Exocrine pancreas; Intestine; Liver; Salivary gland; Stomach

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