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Lancet. 2014 Jan 18;383(9913):257-66. doi: 10.1016/S0140-6736(13)62296-5. Epub 2014 Jan 8.

Increasing value and reducing waste: addressing inaccessible research.

Author information

  • 1Women's College Research Institute, Department of Medicine, Women's College Hospital, University of Toronto, Toronto, ON, Canada. Electronic address: anwen.chan@utoronto.ca.
  • 2Norwich Medical School, Faculty of Medicine and Health Science, University of East Anglia, Norwich, UK.
  • 3Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  • 4The Cochrane Collaboration, Rome, Italy.
  • 5Center for Clinical Trials, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • 6Nordic Cochrane Centre, Rigshospitalet, Copenhagen, Denmark.
  • 7Section of Cardiovascular Medicine and the Robert Wood Johnson Foundation Clinical Scholars Program, Department of Medicine, Yale School of Medicine, Yale University, New Haven, CT, USA; Department of Health Policy and Management, Yale School of Public Health, Yale University, New Haven, CT, USA; Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT, USA.
  • 8Research Translation Branch, National Health and Medical Research Council, Canberra, ACT, Australia.
  • 9Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands.

Abstract

The methods and results of health research are documented in study protocols, full study reports (detailing all analyses), journal reports, and participant-level datasets. However, protocols, full study reports, and participant-level datasets are rarely available, and journal reports are available for only half of all studies and are plagued by selective reporting of methods and results. Furthermore, information provided in study protocols and reports varies in quality and is often incomplete. When full information about studies is inaccessible, billions of dollars in investment are wasted, bias is introduced, and research and care of patients are detrimentally affected. To help to improve this situation at a systemic level, three main actions are warranted. First, academic institutions and funders should reward investigators who fully disseminate their research protocols, reports, and participant-level datasets. Second, standards for the content of protocols and full study reports and for data sharing practices should be rigorously developed and adopted for all types of health research. Finally, journals, funders, sponsors, research ethics committees, regulators, and legislators should endorse and enforce policies supporting study registration and wide availability of journal reports, full study reports, and participant-level datasets.

Copyright © 2014 Elsevier Ltd. All rights reserved.

PMID:
24411650
[PubMed - indexed for MEDLINE]
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