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J Neuroimmunol. 2014 Feb 15;267(1-2):73-85. doi: 10.1016/j.jneuroim.2013.12.009. Epub 2013 Dec 12.

A molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data?

Author information

  • 1La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA. Electronic address: Kvaughan@liai.org.
  • 2La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, USA.
  • 3Department of Neurology, Yale School of Medicine, 300 George Street, New Haven, CT 06511, USA; Human and Translational Immunology Program, Yale School of Medicine, 300 George Street, New Haven, CT 06511, USA.
  • 4Neuroimmunology and MS Research, Department of Neurology, University Hospital Zurich, 8091 Zurich, Switzerland.

Abstract

An analysis to inventory all immune epitope data related to multiple sclerosis (MS) was performed using the Immune Epitope Database (IEDB). The analysis revealed that MS related data represent >20% of all autoimmune data, and that studies of EAE predominate; only 22% of the references describe human data. To date, >5800 unique peptides, analogs, mimotopes, and/or non-protein epitopes have been reported from 861 references, including data describing myelin-containing, as well as non-myelin antigens. This work provides a reference point for the scientific community of the universe of available data for MS-related adaptive immunity in the context of EAE and human disease.

Copyright © 2014 Elsevier B.V. All rights reserved.

KEYWORDS:

Antibody; Epitope; Experimental autoimmune encephalomyelitis (EAE); Multiple sclerosis; T cell

PMID:
24365494
[PubMed - indexed for MEDLINE]
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