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World J Pediatr. 2013 Nov;9(4):293-9. doi: 10.1007/s12519-013-0438-9. Epub 2013 Nov 14.

Type 2 diabetes mellitus in pediatrics: a new challenge.

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  • 1Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.

Abstract

BACKGROUND:

The increased prevalence of childhood obesity in the last few years has been accompanied by the increase in prevalence of type 2 diabetes in pediatrics. In this paper, we will review the risk factors and the pathogenic determinants leading to type 2 diabetes in youth.

DATA SOURCES:

We searched on PubMed with the key words: obesity, type 2 diabetes, children, adolescents, youth, non-alcoholic fatty liver disease, genes and selected those publications written in English that we judged to be relevant to the topic of the review.

RESULTS:

Based on the data present in the literature, we reviewed the following three topics: 1) the role of ectopic fat deposition, in particular of fatty liver, in the pathogenesis of pediatric type 2 diabetes; 2) the progression to type 2 diabetes in pediatrics and how it differs from adults, and 3) current theraputic options.

CONCLUSION:

Type 2 diabetes in youth is a complex disease, creating new challenges in treatment and prevention.

PMID:
24235062
[PubMed - indexed for MEDLINE]
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