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Cancers (Basel). 2011 Oct 11;3(4):3838-55. doi: 10.3390/cancers3043838.

Targeted radionuclide therapy.

Author information

  • 1Department of Diagnostic Radiology, School of Medicine, Yale University, 333 Cedar St., New Haven, CT 06520, USA. devrimersahin@yahoo.com.

Abstract

Targeted radiotherapy is an evolving and promising modality of cancer treatment. The killing of cancer cells is achieved with the use of biological vectors and appropriate radionuclides. Among the many advantages of this approach are its selectiveness in delivering the radiation to the target, relatively less severe and infrequent side effects, and the possibility of assessing the uptake by the tumor prior to the therapy. Several different radiopharmaceuticals are currently being used by various administration routes and targeting mechanisms. This article aims to briefly review the current status of targeted radiotherapy as well as to outline the advantages and disadvantages of radionuclides used for this purpose.

PMID:
24213114
[PubMed]
PMCID:
PMC3763399
Free PMC Article
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