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Cell Stem Cell. 2013 Nov 7;13(5):510-2. doi: 10.1016/j.stem.2013.10.007.

Trivalent chromatin marks the way in.

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  • 1Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, 10 Amistad, 201B, New Haven, CT 06520, USA.


Recently in Cell, Wapinski et al. (2013) investigated the epigenetic mechanisms underlying the direct conversion of fibroblasts to induced neurons (iNs). They found that Ascl1 acts as a pioneer factor at neurogenic loci marked by a closed "trivalent" chromatin state in cells permissive to direct conversion, but not in restrictive cell types.

Copyright © 2013 Elsevier Inc. All rights reserved.

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