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Biol Blood Marrow Transplant. 2014 Mar;20(3):295-308. doi: 10.1016/j.bbmt.2013.10.013. Epub 2013 Oct 17.

Optimizing autologous stem cell mobilization strategies to improve patient outcomes: consensus guidelines and recommendations.

Author information

  • 1Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: GiraltS@mskcc.org.
  • 2Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.
  • 3Cancer Transplant Institute, Virginia G Piper Cancer Center, Scottsdale, Arizona.
  • 4Washington University School of Medicine in St. Louis, St. Louis, Missouri.
  • 5Oregon Health and Science University, Portland, Oregon.
  • 6Adult Bone Marrow Transplant, Virginia Commonwealth University, Richmond, Virginia.
  • 7Adult Bone Marrow Transplant, Texas Transplant Institute, San Antonio, Texas.
  • 8Yale University Medical School, New Haven, Connecticut.
  • 9Fred Hutchinson Cancer Research Institute, Seattle, Washington.
  • 10Levine Cancer Institute I, Carolinas HealthCare System, Charlotte, North Carolina.
  • 11MD Anderson Cancer Center, Houston, Texas.
  • 12Stanford School of Medicine, Stanford, California.
  • 13Intermountain Blood and Marrow Transplant Program, Intermountain Healthcare, Salt Lake City, Utah.
  • 14Section of Hematology/Oncology, University of Illinois at Chicago Cancer Center, Chicago, Illinois.
  • 15Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • 16University of Florida, Gainesville, Florida.
  • 17Adult Bone Marrow Transplant, University of Florida, Gainesville, Florida.
  • 18Department of Internal Medicine/Hematology/Oncology, Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

Abstract

Autologous hematopoietic stem cell transplantation (aHSCT) is a well-established treatment for malignancies such as multiple myeloma (MM) and lymphomas. Various changes in the field over the past decade, including the frequent use of tandem aHSCT in MM, the advent of novel therapies for the treatment of MM and lymphoma, and the addition of new stem cell mobilization techniques, have led to the need to reassess current stem cell mobilization strategies. Mobilization failures with traditional strategies are common and result in delays in treatment and increased cost and resource utilization. Recently, plerixafor-containing strategies have been shown to significantly reduce mobilization failure rates, but the ideal method to maximize stem cell yields and minimize costs associated with collection has not yet been determined. A panel of experts convened to discuss the currently available data on autologous hematopoietic stem cell mobilization and transplantation and to devise guidelines to optimize mobilization strategies. Herein is a summary of their discussion and consensus.

Copyright © 2014 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Chemomobilization; Growth factors; Mobilization; Mobilization failure; Optimal collection; Plerixafor

PMID:
24141007
[PubMed - indexed for MEDLINE]
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