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Ann Surg Oncol. 2013 Oct;20(10):3247-53. doi: 10.1245/s10434-013-3155-7. Epub 2013 Aug 22.

Is there a correlation between breast cancer molecular subtype using receptors as surrogates and mammographic appearance?

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  • 1Department of Surgery, The Breast Center-Smilow Cancer Hospital at Yale-New Haven, Yale University School of Medicine, New Haven, CT, USA. brigid.killelea@yale.edu

Abstract

BACKGROUND:

The identification of distinct molecular subtypes has changed breast cancer management. The correlation between mammographic appearance and molecular subtype for invasive breast cancer has not been extensively studied.

METHODS:

A retrospective review of our prospectively collected database was performed to evaluate the mammographic appearance and molecular subtypes of all cases of invasive breast cancers diagnosed between 2003 and 2010.

RESULTS:

There were 985 cases of invasive breast cancer with complete data on receptor status and mammographic appearance. The most common mammographic finding was a mass (61 %), and the most common molecular subtype was ER/PR positive, HER2 negative (71 %). On univariate analysis, race, stage, and histology were all significantly associated with molecular subtype. On multivariate analysis, the luminal molecular type was associated with architectural distortion [odds ratio (OR) 4.3, 95 % CI 1.3-14.1]; HER2 positive cancers, either with or without ER/PR expression, were more likely to be associated with mammographic calcifications (OR 2.8 and 3.1, respectively; 95 % CI 1.7-4.8 and 1.7-5.5); and triple negative cancers were most likely to be associated with a mammographic mass (OR 2.5; 95 % CI 1.4-4.4).

CONCLUSIONS:

We observed several characteristic associations between molecular subtype and mammographic appearance. Improved understanding of these associations may help guide clinical decision making and provide information about underlying tumor biology.

PMID:
23975299
[PubMed - indexed for MEDLINE]
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