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Pediatr Blood Cancer. 2013 Nov;60(11):E146-8. doi: 10.1002/pbc.24645. Epub 2013 Jul 18.

Myelodysplastic syndrome (MDS)-associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia.

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  • 1Department of Pathology, Parkland Health and Hospital System, Children's Medical Center, UT Southwestern Medical Center, Dallas, Texas.

Abstract

Chronic myelogenous leukemia (CML) is very rare in the pediatric population. We report the case of a 2-year-old female with CML and concurrent myelodysplastic syndrome (MDS) associated cytogenetic abnormalities. The co-existence of t(9;22) and chromosomal deletions that are associated with MDS poses a unique diagnostic challenge. Given the reported association of t(9;22) and genomic instability, we hypothesize that the chromosomal deletions represent clonal evolution of the CML.

Copyright © 2013 Wiley Periodicals, Inc.

KEYWORDS:

chronic myelogenous leukemia; cytogenetics; molecular genetics; myelodysplastic syndrome

PMID:
23868765
[PubMed - indexed for MEDLINE]
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