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Trends Parasitol. 2013 Aug;29(8):394-406. doi: 10.1016/j.pt.2013.06.005. Epub 2013 Jul 8.

Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda.

Author information

  • 1Yale School of Public Health, Department of Epidemiology of Microbial Diseases, Yale University, 60 College Street, New Haven, CT, USA. serap.aksoy@yale.edu

Abstract

Uganda has both forms of human African trypanosomiasis (HAT): the chronic gambiense disease in the northwest and the acute rhodesiense disease in the south. The recent spread of rhodesiense into central Uganda has raised concerns given the different control strategies the two diseases require. We present knowledge on the population genetics of the major vector species Glossina fuscipes fuscipes in Uganda with a focus on population structure, measures of gene flow between populations, and the occurrence of polyandry. The microbiome composition and diversity is discussed, focusing on their potential role on trypanosome infection outcomes. We discuss the implications of these findings for large-scale tsetse control programs, including suppression or eradication, being undertaken in Uganda, and potential future genetic applications.

Copyright © 2013. Published by Elsevier Ltd.

KEYWORDS:

Glossina fuscipes; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Uganda; human African trypanosomiasis; population genetics; sleeping sickness; vector control

PMID:
23845311
[PubMed - indexed for MEDLINE]
PMCID:
PMC3772539
Free PMC Article
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