Format

Send to:

Choose Destination
See comment in PubMed Commons below
Arch Biochem Biophys. 2013 Nov 15;539(2):163-70. doi: 10.1016/j.abb.2013.06.007. Epub 2013 Jun 30.

Resonance Raman spectroscopic evaluation of skin carotenoids as a biomarker of carotenoid status for human studies.

Author information

  • 1Yale School of Public Health and Yale Cancer Center, 60 College St., P.O. Box 208034, New Haven, CT 06520, USA. Electronic address: susan.mayne@yale.edu.

Abstract

Resonance Raman spectroscopy (RRS) is a non-invasive method that has been developed to assess carotenoid status in human tissues including human skin in vivo. Skin carotenoid status has been suggested as a promising biomarker for human studies. This manuscript describes research done relevant to the development of this biomarker, including its reproducibility, validity, feasibility for use in field settings, and factors that affect the biomarker such as diet, smoking, and adiposity. Recent studies have evaluated the response of the biomarker to controlled carotenoid interventions, both supplement-based and dietary [e.g., provision of a high-carotenoid fruit and vegetable (F/V)-enriched diet], demonstrating consistent response to intervention. The totality of evidence supports the use of skin carotenoid status as an objective biomarker of F/V intake, although in the cross-sectional setting, diet explains only some of the variation in this biomarker. However, this limitation is also a strength in that skin carotenoids may effectively serve as an integrated biomarker of health, with higher status reflecting greater F/V intake, lack of smoking, and lack of adiposity. Thus, this biomarker holds promise as both a health biomarker and an objective indicator of F/V intake, supporting its further development and utilization for medical and public health purposes.

Copyright © 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

Beta-carotene; Biomarker; Carotenoids; Resonance Raman spectroscopy; Skin

PMID:
23823930
[PubMed - indexed for MEDLINE]
PMCID:
PMC3818359
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk