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Best Pract Res Clin Haematol. 2013 Mar;26(1):43-56. doi: 10.1016/j.beha.2013.04.005. Epub 2013 May 25.

Treatment strategies for peripheral T-cell lymphomas.

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  • 1Yale University School of Medicine, New Haven, CT, USA. francine.foss@yale.edu

Abstract

Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of clinically aggressive diseases historically associated with inferior outcomes using conventional lymphoma therapies. Aggressive first line therapy and consolidation with autologous stem cell transplantation has led to improved survival, but the majority of patients either fails to respond to therapy or are not transplant candidates. Novel approaches have included new classes of drug and biological agents, including antifolates, immunoconjugates, histone deacetylase (HDAC) inhibitors, monoclonal antibodies, and signal transduction inhibitors. Molecular profiling has led to identification of relevant pathways for future novel approaches.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
23768640
[PubMed - indexed for MEDLINE]
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