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Eur J Cardiothorac Surg. 2013 Jul;44(1):e66-70. doi: 10.1093/ejcts/ezt184. Epub 2013 Apr 4.

Pulmonary resections following prior definitive chemoradiation therapy are associated with acceptable survival.

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  • 1Yale School of Medicine, New Haven, CT 06520, USA.

Abstract

OBJECTIVES:

The benefits of salvage resection for lung cancer recurrence following high-dose curative-intent chemoradiation therapy are unclear. We assessed survival after salvage lung resection following definitive chemoradiation.

METHODS:

Medical records of patients undergoing lung cancer resections at our institution following definitive chemoradiation therapy were reviewed from June 2006 to August 2012. A multivariate Cox proportional model was used to assess the factors associated with improved survival.

RESULTS:

Fourteen patients had chemoradiation therapy before lung resection (pneumonectomy, lobectomy or segmentectomy). Pretherapy cancer stage was Stage III in 11 patients, Stage IV in 2 and Stage II in 1. Postoperative 2-year survival was 49%. Patients had a median disease-free interval before resection of 33 months. No variables were found to be associated with improved post-chemoradiation survival from the time of definitive treatment or postoperative survival. Complications occurred in 6 (43%) patients, with 2 of those complications directly attributable to post-chemoradiation changes. There were no perioperative deaths within 90 days.

CONCLUSIONS:

Salvage lung resection for recurrent lung cancer following definitive chemoradiation therapy is feasible and is associated with postoperative survival and complication rates that are reasonable.

KEYWORDS:

Lung neoplasms; Pneumonectomy; Salvage therapy

PMID:
23557918
[PubMed - indexed for MEDLINE]
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