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Magn Reson Med. 2014 Feb;71(2):451-7. doi: 10.1002/mrm.24701.

Intramolecular zero-quantum-coherence 2D NMR spectroscopy of lipids in the human breast at 7 T.

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  • 1Department of Radiology, UMC Utrecht, Utrecht, The Netherlands; Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University, New Haven, Connecticut, USA.

Abstract

PURPOSE:

Intramolecular zero-quantum-coherences (ZQCs) are intrinsically insensitive toward magnetic field inhomogeneity. This fact is used to quantify and characterize lipid signals in the human breast at 7 T despite the presence of severe magnetic field inhomogeneity caused by water-lipid susceptibility boundaries.

METHODS:

A novel 3D localized 2D ZQC method is presented. The combination of cardiac/respiratory triggering and post-acquisition navigator echo correction provides high-quality 2D NMR spectra in vivo.

RESULTS:

The lipid profile of the human breast could be quantified by 2D ZQC NMR in 100% of the subjects despite a wide range of magnetic field homogeneity. With conventional 1D (1)H MRS, the magnetic field homogeneity was only adequate in 60% of the subjects. The results from 2D ZQC NMR and 1D NMR are in good correspondence, both in vitro and in vivo.

CONCLUSION:

It has been demonstrated that high quality and quantitative 2D ZQC NMR spectra can be acquired from human breast tissue at 7 T. While the simplicity and sensitivity of 1D MRS are preferable when the magnetic field homogeneity is adequate, the 2D ZQC method provides a viable alternative in cases where this requirement cannot be met. Magn Reson Med 71:451-457, 2014. © 2013 Wiley Periodicals, Inc.

Copyright © 2013 Wiley Periodicals, Inc.

PMID:
23468435
[PubMed - in process]
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