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Pediatr Dermatol. 2014 Jul-Aug;31(4):507-10. doi: 10.1111/pde.12071. Epub 2013 Mar 5.

Two cases of hemihyperplasia-multiple lipomatosis syndrome and review of asymmetric hemihyperplasia syndromes.

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  • 1Department of Dermatology, School of Medicine, Yale University, New Haven, Connecticut.


Hemihyperplasia-multiple lipomatosis syndrome (HHML) is a condition characterized by asymmetric nonprogressive overgrowth, multiple lipomas, and superficial vascular malformations. We present two cases of HHML to enhance the diagnostic acumen of dermatologists and avoid potential misdiagnosis of this rare but probably underrecognized entity. We also provide a brief review of asymmetric overgrowth syndromes, which have overlapping yet distinct clinical manifestations.

© 2013 Wiley Periodicals, Inc.

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