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J Pediatr Hematol Oncol. 2014 Jan;36(1):e13-5. doi: 10.1097/MPH.0b013e318282dadf.

Metastatic gastrinoma in a pediatric patient with Zollinger-Ellison syndrome.

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  • 1*Section of Hematology/Oncology, Department of Pediatrics †Yale Stem Cell Center, Yale University School of Medicine ‡Section of Transplantation and Immunology, Department of Surgery §Yale New Haven Transplant Center, New Haven, CT.


Metastatic neuroendocrine tumors of childhood are extremely rare, and as such present diagnostic and therapeutic challenges. Here, we report a case of gastrinoma with extensive hepatic metastases in a pediatric patient with Zollinger-Ellison Syndrome who underwent orthotopic liver transplant followed by cytotoxic chemotherapy, somatostatin analog therapy, and immune modulation.

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