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Allergy. 2013 Apr;68(4):545-8. doi: 10.1111/all.12125. Epub 2013 Feb 15.

Relationship between asthma and cognition: the Cooper Center Longitudinal Study.

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  • 1Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas 75390-8849, USA.



Minimal data are available on the relationship between asthma and cognitive performance. In this report, we examine the relationship between asthma and cognitive performance in older adults, a subpopulation with elevated risk of cognitive impairment.


We conducted a cross-sectional, retrospective analysis of 1380 participants age ≥55 who completed preventive health examinations at the Cooper Clinic in Dallas, TX. Cognition was assessed using the Montreal Cognitive Assessment (MoCA), a brief test for mild cognitive impairment. Data were analyzed in a multiple logistic regression using MoCA scores suggestive of cognitive impairment as the dependent variable.


When controlling for demographic characteristics, self-rated health status, inhaled corticosteroid use, and FEV1 /FVC, asthma were associated with 78% increased risk of cognitive impairment (P = 0.02) as defined by MoCA score.


In the largest sample examined to date, we have identified a significant relationship between asthma and cognitive impairment in older people.

© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.

[PubMed - indexed for MEDLINE]
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