Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pharmacol Ther. 2013 May;138(2):197-210. doi: 10.1016/j.pharmthera.2013.01.008. Epub 2013 Jan 24.

Adipocytes: impact on tumor growth and potential sites for therapeutic intervention.

Author information

  • 1Touchstone Diabetes Center, Departments of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

The prevalence of obesity has increased dramatically in recent decades, reaching epidemic proportions. It is becoming clear that obesity is associated not only with type 2 diabetes mellitus and cardiovascular disease, but also with multiple types of cancer. Obesity is characterized by impaired adipose tissue function, leading to adipocyte hypertrophy, inflammation, hypoxia and induced angiogenesis, extracellular matrix remodeling and fibrosis as well as additional stress responses. While epidemiological data indicate that obesity is a well-established risk factor for certain malignancies, the molecular mechanisms underlying the link between obesity and cancer are still poorly understood. Recent data implicates systemic and paracrine factors secreted from adipose tissue during the obese state, promoting cancer development and progression. Here, we focus on the obesity-associated adipose tissue remodeling that may not only lead to metabolic complications, but also to a permissive pro-tumorigenic environment. Particular attention is given to the local pro-tumorigenic effects derived from adipocytes that present an important part of the tumor microenvironment of at least some cancers, in an attempt to describe the nature of the major players of the adipocyte-cancer cell crosstalk that dictates to a large extent tumor progression.

Copyright © 2013 Elsevier Inc. All rights reserved.

PMID:
23353703
[PubMed - indexed for MEDLINE]
PMCID:
PMC3602387
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk