Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2013 Jan;36(1):51-61. doi: 10.1016/j.tins.2012.09.004. Epub 2012 Oct 11.

Newborn cortical neurons: only for neonates?

Author information

  • 1Department of Neurosurgery, and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Despite a century of debate over the existence of adult cortical neurogenesis, a consensus has not yet been reached. Here, we review evidence of the existence, origin, migration, and integration of neurons into the adult and neonatal cerebral cortex. We find that the lack of consensus likely stems from the low rate of postnatal cortical neurogenesis that has been observed, the fact that neurogenesis may be limited to subtypes of interneurons, and variability in other conditions, both physiological and environmental. We emphasize that neurogenesis occurs in the neonatal cortex and that neural stem cells are present into adulthood; it is possible that these progenitors are dormant, but they may be reactivated, for example, following injury.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
23062965
[PubMed - indexed for MEDLINE]
PMCID:
PMC3534801
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk