Format

Send to:

Choose Destination
See comment in PubMed Commons below
Dev Psychopathol. 2012 Nov;24(4):1443-51. doi: 10.1017/S095457941200082X.

Neurobiology meets genomic science: the promise of human-induced pluripotent stem cells.

Author information

  • 1Yale University School of Medicine, New Haven, CT 06520–7900, USA.

Abstract

The recent introduction of the induced pluripotent stem cell technology has made possible the derivation of neuronal cells from somatic cells obtained from human individuals. This in turn has opened new areas of investigation that can potentially bridge the gap between neuroscience and psychopathology. For the first time we can study the cell biology and genetics of neurons derived from any individual. Furthermore, by recapitulating in vitro the developmental steps whereby stem cells give rise to neuronal cells, we can now hope to understand factors that control typical and atypical development. We can begin to explore how human genes and their variants are transcribed into messenger RNAs within developing neurons and how these gene transcripts control the biology of developing cells. Thus, human-induced pluripotent stem cells have the potential to uncover not only what aspects of development are uniquely human but also variations in the series of events necessary for normal human brain development that predispose to psychopathology.

PMID:
23062309
[PubMed - indexed for MEDLINE]
PMCID:
PMC3513939
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Cambridge University Press Icon for PubMed Central
    Loading ...
    Write to the Help Desk