Format

Send to:

Choose Destination
See comment in PubMed Commons below
Early Hum Dev. 2013 Feb;89(2):81-6. doi: 10.1016/j.earlhumdev.2012.08.001. Epub 2012 Sep 20.

Neurobehavioral assessment of infants born at term and in utero exposure to serotonin reuptake inhibitors.

Author information

  • 1Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. megan.smith@yale.edu

Abstract

BACKGROUND:

Some studies report neurobehavioral symptoms in neonates exposed to serotonin reuptake inhibitors (SRIs) in utero. However, maternal psychiatric illness during the last trimester of pregnancy, as a confounding factor, has not always been assessed.

AIMS:

In this prospective study we compared neurobehavioral complications among neonates who were born to euthymic women who either took or did not take an SRI during the last trimester of pregnancy.

STUDY DESIGN:

Exposed and unexposed infants were assessed for: 1) temperament as measured by the Neonatal Behavioral Assessment Scale (NBAS); 2) activity via Actiwatch electronic monitoring; 3) sleep state using trained observer ratings; and 4) perinatal complications through medical record review. T-tests, Fisher's exact tests, and analyses of covariance were used to assess the relationship between clinical and neurobehavioral factors and exposure status.

SUBJECTS:

67 infants (61 controls and 6 exposed to SRIs).

OUTCOME MEASURES:

Neonatal Assessment Behavioral Scale, APGAR scores, infant sleep state (% sleep, % wakeful), startles and tremulousness, gestational age, birth weight, and head circumference.

RESULTS:

Infants exposed to SRIs in the third trimester had poorer motor development, lower 5-minute APGAR scores, and shorter mean gestational age as compared to unexposed infants.

CONCLUSION:

Results of this study show differences in autonomic and gross motor activity between neonates who were or were not exposed to SRIs in utero after controlling for active maternal psychiatric illness. Future longitudinal work should compare longer term outcomes of exposed and unexposed infants of depressed mothers.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID:
22999988
[PubMed - indexed for MEDLINE]
PMCID:
PMC3921021
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk