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Diabetes Care. 2013 Feb;36(2):289-93. doi: 10.2337/dc12-0198. Epub 2012 Sep 10.

Change in visceral adiposity independently predicts a greater risk of developing type 2 diabetes over 10 years in Japanese Americans.

Author information

  • 1Department of Epidemiology, University of Washington, Seattle, WA, USA. lwander@u.washington.edu

Abstract

OBJECTIVE:

Visceral adiposity is an important risk factor for cardiovascular disease and type 2 diabetes. We sought to determine whether change in intraabdominal fat area (IAF) over time predicts subsequent development of diabetes.

RESEARCH DESIGN AND METHODS:

We followed up 436 nondiabetic Japanese-American subjects (mean age 51.9 years, mean BMI 24.2 kg/m(2), 54% male) for development of diabetes. We fit a logistic regression model to examine the association over a 10-year follow-up between change in IAF at 5-year follow-up and other fat areas (measured by computed tomography) and development of incident diabetes, adjusted for age, sex, family history of diabetes in a first-degree relative, second-generation versus third-generation Japanese American (Nisei vs. Sansei), baseline IAF, BMI, weight change over time, smoking status, physical activity level, and subcutaneous fat (SCF) depot areas.

RESULTS:

Cumulative incidence of diabetes was 20.4% at 10 years. Mean change in IAF was 10.9 cm(2). An increase of 1 SD in IAF was associated with a 1.65-fold increase in the odds of diabetes over 10 years (OR = 1.65, 95% CI 1.21-2.25) after adjusting for the above covariates. This association was also independent of changes in thoracic, thigh, and abdominal SCF, as well as change in weight.

CONCLUSIONS:

We conclude that baseline IAF and accumulation of fat in this area over time are independent predictors of the development of type 2 diabetes in Japanese Americans.

PMID:
22966093
[PubMed - indexed for MEDLINE]
PMCID:
PMC3554282
Free PMC Article
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