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Cell Stem Cell. 2012 Aug 3;11(2):139-40. doi: 10.1016/j.stem.2012.07.013.

Chromatin and pluripotency: the MYSTerious connection.

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  • 1Yale Stem Cell Center, Department of Genetics, Yale University, New Haven, CT 06520, USA.


Although histone acetylation is critical for maintaining embryonic stem cell pluripotency, the molecular machinery involved remains poorly understood. Li et al. (2012) now show that Mof, a MYST family histone acetyltransferase, functions as a coactivator of Nanog-mediated transcription, maintains the expression of pluripotency-associated genes, and primes developmental genes for differentiation.

Copyright © 2012 Elsevier Inc. All rights reserved.

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