Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Reprod Immunol. 2012 Aug;68(2):146-53. doi: 10.1111/j.1600-0897.2012.01148.x. Epub 2012 May 8.

Toll-like receptor 4 expression in decidual cells and interstitial trophoblasts across human pregnancy.

Author information

  • 1Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA. Frederick.Schatz@osumc.edu

Abstract

PROBLEM:

Toll-like receptor-4 (TLR-4) protects against Gram-negative bacteria expressed lipopolysaccharide and 'danger signals' from injured or dying cells. Although decidual cells (DCs) and interstitial trophoblasts (ITs) are in close contact, TLR-4 has been studied extensively only in ITs.

METHOD OF STUDY:

Formalin-fixed, paraffin-embedded serial sections of endometrium in follicular and luteal phases and deciduas from first and second trimester elective terminations and third trimester normal deliveries were immunostained for TLR-4, trophoblast-specific cytokeratin, and DC-specific vimentin. HSCORE assessed TLR-4 immunostaining in DCs versus ITs.

RESULTS:

TLR-4 HSCORES were significantly higher in: (i) first trimester DCs than luteal phase pre-decidual stromal cells; (ii) first and third versus second trimester DCs, but similar between third trimester deciduas parietalis and basalis; (iii) first versus second trimester ITs; (iv) DCs versus ITs across gestation.

CONCLUSION:

Higher TLR-4 in DCs than ITs suggests DCs as primary targets for Gram-negative bacteria and/or inflammation-related danger signals.

© 2012 John Wiley & Sons A/S.

PMID:
22564191
[PubMed - indexed for MEDLINE]
PMCID:
PMC3395732
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing Icon for PubMed Central
    Loading ...
    Write to the Help Desk