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Cell Stem Cell. 2012 May 4;10(5):482-3. doi: 10.1016/j.stem.2012.04.014.

PSA lo and behold: prostate cancer stem cells.

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  • University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109-5942, USA. mwicha@umich.edu


Human prostate cancers contain multiple cell populations marked by varying levels of the differentiation marker prostate-specific antigen (PSA). In this issue of Cell Stem Cell, Qin et al. (2012) show that PSA(-/lo) cells are enriched for cells with tumor-initiating characteristics and may participate in resistance to androgen-ablative therapies.

Copyright © 2012 Elsevier Inc. All rights reserved.

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