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Proc Am Thorac Soc. 2012 May;9(2):57-61. doi: 10.1513/pats.201112-056MS.

Chitinase-like proteins in lung injury, repair, and metastasis.

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  • 1Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520-8056, USA.

Abstract

This report explains how our studies of asthma and Th2 inflammation led us to investigate the roles of chitinase-like proteins (CLPs) in lung injury and repair and puts forth an overall hypothesis that can explain the roles that these moieties play in biology and a hypothesis regarding the ways that dysregulated CLP expression may contribute to the pathogenesis of a variety of diseases. We test this hypothesis by assessing the contributions of the CLP breast regression protein (BRP)-39 in the pathogenesis of malignant melanoma metastasis to the lung.

PMID:
22550243
[PubMed - indexed for MEDLINE]
PMCID:
PMC3359113
Free PMC Article
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