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Cleve Clin J Med. 2012 Mar;79(3):182-91. doi: 10.3949/ccjm.79a.09169.

Putting genome analysis to good use: lessons from C-reactive protein and cardiovascular disease.

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  • 1Department of Genetics, Kaiser Permanente Oakland Medical Center, Oakland, CA 94611-5693, USA. leslie.c.manace@kp.org


New methods of studying the human genome offer novel ways to examine the relationship between biomarkers and common, chronic human diseases. As an example, we will review a large genomics study (Elliott et al, JAMA 2009; 302:37-48) that concluded that C-reactive protein (CRP) is likely not a cause of coronary heart disease, although it is a marker for it.

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