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Semin Cell Dev Biol. 2012 Jun;23(4):473-80. doi: 10.1016/j.semcdb.2012.02.005. Epub 2012 Feb 20.

Notch and disease: a growing field.

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  • 1Department of Neurosurgery and Neurobiology, Program on Neurogenetics, Yale School of Medicine, New Haven, CT, United States. angeliki.louvi@yale.edu

Abstract

Signals through the Notch receptors are used throughout development to control cellular fate choices. Our intention here is to provide an overview of the involvement of Notch signaling in human disease, which, keeping pace with the known biology of the pathway, manifests itself in a pleiotropic fashion. A pathway with such broad action in normal development, a profound involvement in the biology of adult stem cells and intricate and complex controls governing its activity, poses numerous challenges. We provide an overview of Notch related pathologies identified thus far and emphasize aspects that have been modeled in experimental systems in order to understand the underlying pathobiology and, hopefully, help the definition of rational therapeutic avenues.

Copyright © 2012. Published by Elsevier Ltd.

PMID:
22373641
[PubMed - indexed for MEDLINE]
PMCID:
PMC4369912
Free PMC Article
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