Format

Send to:

Choose Destination
See comment in PubMed Commons below
Adv Drug Deliv Rev. 2012 May 15;64(7):701-5. doi: 10.1016/j.addr.2011.12.006. Epub 2011 Dec 20.

Polymeric nanoparticles for drug delivery to the central nervous system.

Author information

  • 1Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06511 USA.

Abstract

The central nervous system (CNS) poses a unique challenge for drug delivery. The blood-brain barrier significantly hinders the passage of systemically delivered therapeutics and the brain extracellular matrix limits the distribution and longevity of locally delivered agents. Polymeric nanoparticles represent a promising solution to these problems. Over the past 40years, substantial research efforts have demonstrated that polymeric nanoparticles can be engineered for effective systemic and local delivery of therapeutics to the CNS. Moreover, many of the polymers used in nanoparticle fabrication are both biodegradable and biocompatible, thereby increasing the clinical utility of this strategy. Here, we review the major advances in the development of polymeric nanoparticles for drug delivery to the CNS.

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID:
22210134
[PubMed - indexed for MEDLINE]
PMCID:
PMC3323692
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk