Format

Send to:

Choose Destination
See comment in PubMed Commons below
Stem Cells. 2012 Mar;30(3):491-9. doi: 10.1002/stem.1003.

Nonhematopoietic cells are the primary source of bone marrow-derived lung epithelial cells.

Author information

  • 1Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520-8035, USA. Susannah.Kassmer@Yale.edu

Abstract

Previous studies have demonstrated that bone marrow (BM)-derived cells differentiate into nonhematopoietic cells of multiple tissues. To date, it remains unknown which population(s) of BM cells are primarily responsible for this engraftment. To test the hypothesis that nonhematopoietic stem cells in the BM are the primary source of marrow-derived lung epithelial cells, either wild-type hematopoietic or nonhematopoietic BM cells were transplanted into irradiated surfactant-protein-C (SPC)-null mice. Donor-derived, SPC-positive type 2 pneumocytes were predominantly detected in the lungs of mice receiving purified nonhematopoietic cells and were absent from mice receiving purified hematopoietic stem and progenitor cells. We conclude that cells contained in the nonhematopoietic fraction of the BM are the primary source of marrow-derived lung epithelial cells. These nonhematopoietic cells may represent a primitive stem cell population residing in adult BM.

Copyright © 2011 AlphaMed Press.

PMID:
22162244
[PubMed - indexed for MEDLINE]
PMCID:
PMC3725285
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk