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Org Lett. 2011 Dec 16;13(24):6580-3. doi: 10.1021/ol202944g. Epub 2011 Nov 22.

Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp.

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  • 1Department of Biochemistry, Division of Chemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.


Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of mixed biosynthetic origin containing a tetrasubstituted benzothiazole, an appended diterpene side chain, and a glycine unit. Erythrazole B is cytotoxic to a panel of non-small cell lung cancer (NSCLC) cell lines, with IC(50) values of 1.5, 2.5, and 6.8 μM against H1325, H2122, and HCC366, respectively.

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