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Cardiovasc Diabetol. 2011 Nov 20;10:99. doi: 10.1186/1475-2840-10-99.

Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes.

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  • 1Barbara Davis Center for Childhood Diabetes, Aurora, CO, USA.

Abstract

BACKGROUND:

Coronary artery disease has been linked with genotypes for haptoglobin (Hp) which modulates extracorpuscular hemoglobin. We hypothesized that the Hp genotype would predict progression of coronary artery calcification (CAC), a marker of subclinical atherosclerosis.

METHODS:

CAC was measured three times in six years among 436 subjects with type 1 diabetes and 526 control subjects participating in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study. Hp typing was performed on plasma samples by polyacrylamide gel electrophoresis.

RESULTS:

The Hp 2-2 genotype predicted development of significant CAC only in subjects with diabetes who were free of CAC at baseline (OR: 1.95, 95% CI: 1.07-3.56, p = 0.03), compared to those without the Hp 2-2 genotype, controlling for age, sex, blood pressure and HDL-cholesterol. Hp 2 appeared to have an allele-dose effect on development of CAC. Hp genotype did not predict CAC progression in individuals without diabetes.

CONCLUSIONS:

Hp genotype may aid prediction of accelerated coronary atherosclerosis in subjects with type 1 diabetes.

PMID:
22098782
[PubMed - indexed for MEDLINE]
PMCID:
PMC3231951
Free PMC Article
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