Format

Send to:

Choose Destination
See comment in PubMed Commons below

Vessel connectivity using Murray's hypothesis.

Author information

  • 1Department of Diagnostic Radiology, Yale University, New Haven, CT, USA.

Abstract

We describe a new method for vascular image analysis that incorporates a generic physiological principle to estimate vessel connectivity, which is a key issue in reconstructing complete vascular trees from image data. We follow Murray's hypothesis of the minimum work principle to formulate the problem as an optimization problem. This principle reflects a global property of any vascular network, in contrast to various local geometric properties adopted as constraints previously. We demonstrate the effectiveness of our method using a set of microCT mouse coronary images. It is shown that the performance of our method has a statistically significant improvement over the widely adopted minimum spanning tree methods that rely on local geometric constraints.

PMID:
22003740
[PubMed - indexed for MEDLINE]
PMCID:
PMC3367766
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk