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Am J Obstet Gynecol. 2012 Jan;206(1):72.e1-7. doi: 10.1016/j.ajog.2011.07.033. Epub 2011 Jul 29.

Folic acid supplementation in early pregnancy and asthma in children aged 6 years.

Author information

  • 1Yale Center for Perinatal, Pediatric, and Environmental Epidemiology, Yale School of Public Health, New Haven, CT 06510, USA. michael.bracken@yale.edu

Abstract

OBJECTIVE:

The objective of the study was to assess whether folic acid intake during the first trimester of pregnancy is related to asthma in the offspring by the age of 6 years.

STUDY DESIGN:

This was a prospective cohort study of 1499 women who were followed up from the first trimester of pregnancy. Their children were followed up until they were 6 years old.

RESULTS:

Fifty-one percent of the women used folic acid in the month before conception and 88% in the third month of pregnancy. The adjusted odds ratio for asthma per 100 μm increase in the average daily intake of folic acid was 0.98 (95% confidence interval, 0.93-1.04). For categories of daily folate intake, there was no evidence of associations with childhood asthma or evidence of any dose response relation for any time period (all P(trend) > .05).

CONCLUSION:

Our results do not support any association of folic acid supplementation in pregnancy and asthma risk in offspring by age 6 years.

Copyright © 2012 Mosby, Inc. All rights reserved.

PMID:
21982024
[PubMed - indexed for MEDLINE]
PMCID:
PMC3246127
Free PMC Article
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