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Cell. 2011 Sep 16;146(6):851-4. doi: 10.1016/j.cell.2011.08.041. Epub 2011 Sep 9.

Molecular mechanism of protein folding in the cell.

Author information

  • 1Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8002, USA. james.rothman@yale.edu

Abstract

F.-Ulrich Hartl and Arthur Horwich will share this year's Lasker Basic Medical Science Award for the discovery of the cell's protein-folding machinery, exemplified by cage-like structures that convert newly synthesized proteins into their biologically active forms. Their fundamental findings reveal mechanisms that operate in normal physiologic processes and help to explain the problems that arise in diseases of protein folding.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21907398
[PubMed - indexed for MEDLINE]
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