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Bioorg Med Chem. 2011 Sep 1;19(17):5183-9. doi: 10.1016/j.bmc.2011.07.013. Epub 2011 Jul 20.

Chromomycin SA analogs from a marine-derived Streptomyces sp.

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  • 1Department of Biochemistry, Division of Chemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA.

Abstract

Two chromomycin SA analogs, chromomycin SA(3) and chromomycin SA(2), along with deacetylchromomycin A(3) and five previously reported chromomycin analogs were isolated from a marine-derived Streptomyces sp. The structures of the new compounds were determined by spectroscopic methods including 1D and 2D NMR techniques, HRMS and chemical methods. Chromomycin SA(3) and chromomycin SA(2) are the first naturally occuring chromomycin analogs with truncated side-chains. Biological evaluation of chromomycin analogs for cytotoxicity against two non-small cell lung cancer (NSCLC) cell-lines, A549 and HCC44, demonstrated a decrease in cytotoxicity for the truncated sides chain chromomycin analogs.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21807523
[PubMed - indexed for MEDLINE]
PMCID:
PMC3159829
Free PMC Article
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