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Nat Rev Immunol. 2011 Jun;11(6):427-35. doi: 10.1038/nri2990. Epub 2011 May 20.

Fibrocytes: emerging effector cells in chronic inflammation.

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  • 1Yale University School of Medicine, Section of Pulmonary and Critical Care Medicine, New Haven, Connecticut 06520, USA.

Abstract

Fibrocytes are mesenchymal cells that arise from monocyte precursors. They are present in injured organs and have both the inflammatory features of macrophages and the tissue remodelling properties of fibroblasts. Chronic inflammatory stimuli mediate the differentiation, trafficking and accumulation of these cells in fibrosing conditions associated with autoimmunity, cardiovascular disease and asthma. This Opinion article discusses the immunological mediators controlling fibrocyte differentiation and recruitment, describes the association of fibrocytes with chronic inflammatory diseases and compares the potential roles of fibrocytes in these disorders with those of macrophages and fibroblasts. It is hoped that this information prompts new opportunities for the study of these unique cells.

PMID:
21597472
[PubMed - indexed for MEDLINE]
PMCID:
PMC3599774
Free PMC Article
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