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Nat Med. 2011 Jun;17(6):673-5. doi: 10.1038/nm.2389. Epub 2011 May 3.

Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.

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  • 1Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.

Abstract

CD4(+)CD25(high)CD127(low/-) forkhead box p3 (Foxp3)(+) regulatory T cells (T(reg) cells) possess functional plasticity. Here we describe a higher frequency of T helper type 1 (T(H)1)-like, interferon-γ (IFN-γ)-secreting Foxp3(+) T cells in untreated subjects with relapsing remitting multiple sclerosis (RRMS) as compared to healthy control individuals. In subjects treated with IFN-β, the frequency of IFN-γ(+)Foxp3(+) T cells is similar to that in healthy control subjects. In vitro, human T(reg) cells from healthy subjects acquire a T(H)1-like phenotype when cultured in the presence of interleukin-12 (IL-12). T(H)1-like T(reg) cells show reduced suppressive activity in vitro, which can partially be reversed by IFN-γ-specific antibodies or by removal of IL-12.

PMID:
21540856
[PubMed - indexed for MEDLINE]
PMCID:
PMC3675886
Free PMC Article
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